Bone and joint health conditions are leading global causes of morbidity and disability, costing billions in healthcare expenditure and lost earnings. More specifically, recent findings suggest that 40% of people over 70 years of age suffer from Osteoarthritis (OA) of the knee, 80% of whom have some limitation of movement and 25% are unable to perform major daily life activities. While OA increases with aging, for many other reasons (active lifestyles, injuries, obesity, and others TBD) its incidence and prevalence are increasing. Unfortunately, as of 2007, there is no simple “cure” for OA and there are no known treatments which can predictably slow its progression.
Our team made the strategic decision to implement a ‘4-pillar’ project plan with an integrated approach to discovering better diagnostics and therapeutics for patients while creating common platforms that will inform and prioritize the various mechanisms of this disease and ultimately define the relative risks of disease progression in individuals.